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The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may bring about a rise in methadone plasma concentrations, which could bring about probably fatal respiratory melancholy. Furthermore, discontinuation of concomitantly used cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also end in an increase i